DNA strand exchange and hydrophobic interactions between biomolecules
نویسنده
چکیده
2015 Ungefär 100 kilo ATP syntetiseras i kroppen varje dag av ATP-syntas, ett sammansatt proteinkomplex med tre aktiva centra. Komplexet sitter förankrat i ett biologiskt membran med hjälp av hydrofob attraktion och består av en roterande och en statisk del. En ATP-molekyl syntetiseras per tredjedels varv. Trots att varje aktivt centrum skulle kunna fungera oberoende av de andra, sparas mycket energi av att de enskilda reaktionerna fördelas jämnt över tiden. I artikel 6 i denna avhandling kallar vi detta fenomen för ”katalys genom fasförskjutning”.
منابع مشابه
Evidence for hydrophobic catalysis of DNA strand exchange.
The catalytic role of hydrophobic co-solutes in DNA strand exchange is demonstrated by FRET kinetics. Two mechanisms that contribute to this are base stacking destabilisation and nucleation-promoted DNA strand invasion. We propose that hydrophobic catalysis is involved in the strand-exchange activity of recombination enzymes.
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تاریخ انتشار 2015